The state mindfulness scale for physical activity: further psychometrics properties / Escala de estado de mindfulness para atividade física: novas propriedades psicométricas / Escala de mindfulness en la actividad física: nuevas propiedades psicométricas

Mindfulness has been defined as attention and awareness to the present with an attitude of openness, non-judgment, and acceptance. It is suggested that mindfulness can positively influence experiences in sports and physical activity, increasing adherence to these activities. This study aimed to examine new psychometric properties of the State Mindfulness Scale for Physical Activity (SMS-PA) using classical and modern testing theories among Brazilian sport and exercise practitioners. Two studies were conducted. In the first, with 617 Brazilian sports practitioners, confirmatory factor analysis supported the bifactor structure of the SMS-PA composed of two specific (mental and body mindfulness) and one general factor (state mindfulness), which did not vary among genders. The Rasch Rating Scale Model (RSM) supported essential one-dimensionality indicated by the general factor with good item fit statistics (infit/outfit 0.62-1.27). The model presented a good level of Rasch reliability (0.85), and the items difficulty estimation provided an understanding of the continuum represented by their content. In the second study, with 249 Brazilian exercise practitioners, the structural equation modeling showed that Body Mindfulness was associated with positive outcomes (positive affect and satisfaction with practice). The mediation analysis showed that people with higher levels of Body mindfulness tend to experience greater levels of Positive Affect and, consequently, greater Satisfaction with exercises. The results suggest that the Brazilian version of the SMS-PA is an appropriate measure of the state of mindfulness.(AU)

Mindfulness pode ser definido como atenção e consciência no momento presente com uma atitude de abertura, não julgamento e aceitação. A literatura sugere que o mindfulness pode influenciar positivamente experiências no esporte e atividade física e pode exercer um papel na adesão a essas atividades. Este estudo teve como objetivo investigar novas propriedades psicométricas da State Mindulness Sacale for Physical Activity (SMS-PA) utilizando as teorias clássicas e modernas dos testes em praticantes de exercício físico e esporte brasileiros. Dois estudos foram conduzidos. No primeiro, com 617 brasileiros praticantes de esporte, a Análise Fatorial Confirmatória (AFC) demonstrou adequação à estrutura bifatorial da SMS-PA composta por dois fatores específicos (mindfulness mental e físico) e um fator geral (estado de mindfulness), que apresentou invariância entre sexos. A Rasch Rating Scale Model (RSM) corroborou a unidimensionalidade essencial indicada pelo fator geral com bons índices de ajustes (infit/outfit 0.62 -1.27). O modelo apresentou bom nível de precisão Rasch (.85), e a estimação de dificuldade dos itens possibilitou compreensão do continuum representado pelo conteúdo dos itens. No segundo estudo, com 249 brasileiros praticantes de esporte, a Modelagem de Equações Estruturais demonstrou que o mindfulness físico esteve associado a afetos positivos e satisfação com a prática. A análise de mediação mostrou que pessoas com níveis altos de mindfulness físico tendem a apresentar níveis mais elevados de afeto positivo e, consequentemente, níveis mais elevados de satisfação com a prática. Os resultados sugerem que a versão brasileira do SMS-PA é uma medida apropriada do estado de mindfulness para atividades físicas.(AU)

La atención plena puede definirse como la atención y la conciencia en el momento presente con una actitud de apertura, no juicio y aceptación. La literatura sugiere que el mindfulness puede influir positivamente en las experiencias en el deporte y en la actividad física, además de desempeñar un papel en la adherencia a estas actividades. Este estudio tuvo como objetivo investigar nuevas propiedades psicométricas de la State Mindfulness Scale for Physical Activity (SMS-PA) utilizando las teorías clásicas y modernas de las pruebas en practicantes de ejercicio físico y de deporte en Brasil. Para ello, se realizaron dos estudios. En el primer, participaron 617 practicantes de deporte brasileños, y el análisis factorial confirmatorio (AFC) demostró adecuación en la estructura bifactorial de la SMS-PA, compuesta por dos factores específicos (mindfulness mental y físico) y un factor general (estado de mindfulness), que mostró invarianza entre sexos. El Rasch Rating Scale Model (RSM) corroboró la unidimensionalidad esencial indicada por el factor general con buenos índices de ajuste (infit/outfit 0,62-1,27). El modelo mostró un buen nivel de precisión de Rasch (.85), y la estimación de la dificultad de los ítems permitió comprender el continuo representado por el contenido de estos. En el segundo estudio, con 249 practicantes de deporte, el modelo de ecuaciones estructurales mostró que el mindfulness físico estaba asociado a resultados positivos (afecto positivo y satisfacción con la práctica). El análisis de mediación reveló que las personas con altos niveles de mindfulness físico tendían a tener mayores niveles de afecto positivo y, en consecuencia, mayores niveles de satisfacción con la práctica. Los resultados sugieren que la versión brasileña de la SMS-PA es una medida adecuada de mindfulness.(AU)

Situación nutricional entre los percentiles ecuatorianos y la OMS en adolescentes del 12 años / Nutritional situation between ecuadorian and who percentile in 12-year-old adolescents

Se trata de la recopilación de información sobre estudios que reflejan la situación nutricional en Ecuador, y las comparaciones entre los percentiles ecuatorianos y los que sugiere la Organización Mundial de la Salud (OMS). Estudios refieren que este tipo de comparación difiere de las realidades de un país pues presenta diferente ubicación geográfica y por sus rasgos culturales, que difieren ancestralmente se presentan divergencias entre la alimentación, estilos de vida, bases socioeconómicas, rasgos antropométricos y otras variables que influyen y que han obligado a crear sus propios estándares de comparaciones. Objetivo: Describir la situación nutricional entre los percentiles ecuatorianos y la OMS en adolescentes de 12 años. Materiales y método: Es del tipo cualitativa, descriptiva, donde se recopila información relevante vinculada al descriptor en estudio, por eso la modalidad es tipo documental y descriptiva, transversal y observacional porque se le y observa información relevante de momento y se describe y señalan procedimientos como modelos para otras investigaciones. Resultados: Ecuador como país latinoamericano refleja una situación alimentaria y nutricional de amplio potencial productivo, de grandes oportunidades y capacidades socioeconómicas, necesarios para dar respuestas a las exigencias nutricionales de su población. Sin embargo, la información sobre el estado nutricional de la población infantil refleja el desarrollo del país, con una reducción significativa de la prevalencia de retardo de crecimiento, que prevalecen mucho más en grupos indígenas, por problemas sociales: mortalidad infantil, pobreza, indigencia y analfabetismo. Conclusiones: Estimar valores de desnutrición y sobrepeso a través de comparaciones por los percentiles internacionales (WHO) y los de Estados Unidos no reflejan la realidad de una población que difiere en todo con la de esos estándares comparativos. Por ello el esfuerzo de estudios por crear sus propios estándares nacionales es loable y muestra las realidades de una población(AU)

This is the collection of information on studies that reflect the nutritional situation in Ecuador, and comparisons between Ecuadorian percentiles and those suggested by the World Health Organization (WHO). Studies report that this type of comparison differs from the realities of a country because it has different geographical location and its cultural features, which differ ancestrally, there are divergences between food, lifestyles, socioeconomic bases, anthropometric traits and other variables that influence and that have forced to create their own standards of comparisons. Objective: To describe the nutritional situation between the Ecuadorian and WHO percentiles in 12-year-old adolescents Materials and methods: It is of the qualitative, descriptive type, where relevant information linked to the descriptor in study is collected, so the modality is documentary and descriptive, transversal and observational because relevant information is observed at the moment and procedures are described and indicated as models for another research. Results: Ecuador as a Latin American country reflects a food and nutritional situation with ample productive potential, great opportunities and socioeconomic capacities, necessary to respond to the nutritional demands of its population. However, information on the nutritional status of the child population reflects the development of the country, with a significant reduction in the prevalence of growth retardation, which is much more prevalent in indigenous groups, due to social problems: infant mortality, poverty, indigence and illiteracy. Conclusions: Estimating values of malnutrition and overweight through comparisons by the international percentiles (WHO) and those of the United States do not reflect the reality of a population that differs in everything with that of these comparative standards. That is why the effort of studies to create their own national standards is laudable and shows the realities of a population(AU)

Diabetes, hiperglucemia y evolución de pacientes con la COVID-19 / Diabetes, hyperglycemia and evolution of patients with COVID-19

Introducción: La diabetes mellitus e hiperglucemia, en pacientes con la COVID-19, predisponen a mayor gravedad de la enfermedad y peores resultados a corto plazo. Objetivo: Identificar diferencias clínicas, de parámetros humorales, evolución y en el uso de medicamentos en pacientes infectados con el SARS-CoV-2, en relación con el estado glucémico, durante la pandemia de la COVID-19. Métodos: Estudio retrospectivo, de todos los pacientes infectados con SARS-CoV-2, atendidos en el Hospital Militar Dr. Mario Muñoz Monroy, desde el 17 de marzo hasta el 4 de junio de 2020. Se recopilaron variables demográficas, evolución de los síntomas, estadía hospitalaria, antecedentes patológicos personales, parámetros humorales al ingreso, complicaciones y uso de medicamentos. Fueron creados tres grupos: diabéticos (n = 16), hiperglucémicos (glucemia en ayunas ≥ 7,8 mmol/L; n = 10) y normoglucémicos (n = 219). Se utilizaron las pruebas de ji cuadrado y H de Kruskal - Wallis, para las comparaciones entre los grupos. Se usó un intervalo de confianza del 95 por ciento. Resultados: Los pacientes diabéticos e hiperglucémicos, en relación con normoglucémicos, tuvieron mayor proporción de sintomáticos al ingreso, hipertensión arterial, cardiopatía isquémica, insuficiencia renal crónica, otros antecedentes, complicaciones, mortalidad, uso de esteroides y Jusvinza. Además, tuvieron menores valores de hematocrito y linfocitos, mayores de neutrófilos, plaquetas, creatinina, aspartato amino transferasa, glutamil transpeptidasa, fosfatasa alcalina y deshidrogenasa láctica. Conclusiones: Tanto la diabetes como la hiperglucemia predisponen a formas clínicas más graves de COVID-19, con peores parámetros humorales, evolución y mayor mortalidad. En estos pacientes se usa con mayor frecuencia esteroides y Jusvinza(AU)

Introduction: Diabetes mellitus and hyperglycemia, in patients with COVID-19, predispose to greater severity of the disease and worse short-term outcomes. Objective: To identify clinical differences, of humoral parameters, evolution and in the use of medications in patients infected with SARS-CoV-2; in relation to glycemic status, during the COVID-19 pandemic. Methods: Retrospective study of all patients infected with SARS-CoV-2, treated at the Hospital Militar Dr. Mario Muñoz Monroy _until June/2020. Demographic variables, evolution of symptoms, hospital stay, personal pathological history, humoral parameters on admission, complications and use of medications were collected. Three groups were created: diabetic (n = 16), hyperglycemic (fasting blood glucose ≥ 7.8 mmol/L; n = 10) and normo glycemic (n = 219). Chi-square and Kruskal-Wallis H test were used for comparisons between groups. A 95 percent confidence interval was used. Results: Diabetic and hyperglycemic patients had a higher proportion of symptoms on admission, arterial hypertension, ischemic heart disease, chronic renal insufficiency, other antecedents, complications, mortality, and use of steroids and Jusvinza. In addition, they had lower values of hematocrit and lymphocytes, and higher values of neutrophils, platelets, creatinine, aspartate amino transferase, glutamyl transpeptidase, alkaline phosphatase and lactic dehydrogenase. Conclusions: Both diabetes and hyperglycemia predisposed to more severe clinical forms of COVID-19, with worse humoral parameters, evolution and higher mortality. Steroids and Jusvinza were used more frequently in these patients(AU)

Mortalidade adulta por nível de escolaridade em São Paulo: análise comparativa a partir de diferentes estratégias metodológicas / Mortalidad adulta por nivel de escolaridad en San Pablo: análisis comparativo a partir de diferentes estrategias metodológicas / Adult mortality by education level in São Paulo: comparative analysis based on different methodological strategies

Neste artigo, são estimados os diferenciais educacionais de mortalidade de adultos residentes em São Paulo. É realizada uma análise comparativa de estimativas a partir de dados do Censo 2010 e do Sistema de Informação de Mortalidade (SIM) - Datasus e de três formas distintas de mensuração da escolaridade: registrada no SIM; declarada no Censo para o responsável pelo domicílio; e imputada estatisticamente no Censo para indivíduos que morreram. Para as imputações da escolaridade, utilizou-se o método de Dempester (1977), que propõe o uso do algoritmo esperança-maximização (algoritmo E-M) para lidar com dados faltantes. Foram considerados três níveis de escolaridade (baixo, médio e alto) e estimadas as taxas de mortalidade com base em modelos Poisson. Os resultados indicam que a obtenção de escolaridade pode reduzir em até 77% as taxas de mortalidade entre 25 e 59 anos de idade. Além disso, em um país em que a população tem baixa escolaridade, obter ensino médio representa um ganho significativo do ponto de vista da sobrevivência adulta (cerca de 50%). Encontraram-se padrões de mortalidade por escolaridade semelhantes para as estimativas obtidas com dados registrados no SIM e aqueles imputados no Censo 2010. Além disso, a análise sugere que estimativas assumindo a escolaridade do responsável pelo domicílio resultam em diferenciais de mortalidade atípicos, provavelmente distorcidos pela transição de educação no Brasil. Espera-se que o modelo de imputação proposto aqui possa ser utilizado em futuras análises dos dados de mortalidade a partir do Censo 2010.

En este artículo estimamos los diferenciales educativos de la mortalidad de adultos en San Pablo. Ofrecemos un análisis comparativo de estimaciones con base en datos del censo de 2010 y el Sistema de Información de Mortalidad (SIM) - Datasus, y tres formas diferentes de medir la escolaridad: registrada en el SIM, declarada en el censo por el jefe de hogar e imputado estadísticamente en el censo para las personas fallecidas. Para las imputaciones de escolaridad se utilizó el método de Dempester (1977), que propone el uso del algoritmo de maximización de esperanza (algoritmo E-M) para tratar los datos faltantes. Consideramos tres niveles de educación (bajo, medio y alto) y estimamos las tasas de mortalidad con base en los modelos de Poisson. Los resultados indican que la escolarización puede reducir las tasas de mortalidad entre los 25 y 59 años hasta en un 77 %. Además, en un país donde la población tiene bajo nivel de educación, completar la educación secundaria representa una ganancia significativa desde el punto de vista de la supervivencia de los adultos (alrededor del 50%). Encontramos patrones similares de mortalidad por educación para las estimaciones obtenidas con datos registrados en el SIM y datos imputados en el Censo de 2010. Además, nuestro análisis sugiere que las estimaciones asumiendo la educación del jefe de hogar dan como resultado diferenciales de mortalidad atípicos, probablemente distorsionados por la transición de educación en Brasil. Esperamos que el modelo de imputación propuesto aquí se pueda utilizar en futuros análisis de mortalidad del Censo de 2010.

In this article, we estimate adult mortality by education level in São Paulo. We compare estimates based on deaths from the 2010 Census and the 2013 Mortality Information System (Sistema de Informação de Mortalidade - SIM) - DATASUS, and three different ways of measuring education level: recorded in the SIM, reported in the census for the household heads and imputed statistically in the census for individuals who died. For the statistical imputation, we use the Dempester (1977) method, which proposes using the expectation-maximization algorithm (EM algorithm) to deal with missing data. We consider three education levels (low, medium, and high) and estimate mortality rates based on Poisson models. The results indicate that between ages 25 and 59, more years of schooling are associated with mortality rates up to 77% lower. Secondary (medium) education level provides most of the mortality gains at adult ages (about 50%). The mortality differentials calculated with death records from the SIM and census deaths with education imputed statistically are similar. However, estimates based on the assumption that the deceased's education is equal to the household head's in the census resulted in atypical mortality patterns. We hope that the imputation model we propose in the current study can be used in future mortality analyses by SES using census deaths.

Protocolo modelo para la recolección, resguardo, preservación y cadena de custodia de evidencia biológica en casos de abuso sexual contra niñas, niños y adolescentes / Model protocol for the collection, protection, preservation and chain of custody of biological evidence in cases of sexual abuse against girls, boys and adolescents

El abuso sexual contra niñas, niños y adolescentes (NNyA) es una de las vulneraciones más graves de derechos contra la niñez y adolescencia y constituye un problema social, de salud y de justicia La magnitud del problema se ve en los números. La Oficina de Violencia Doméstica (OVD) de la Corte Suprema de Justicia de la Nación señala que las denuncias por violencia sexual representaron un 10% del total de las denuncias recibidas durante el 2019. En los casos de violencia sexual contra NNyA el porcentaje asciende a un 12%. En esta misma línea, del total de los casos que atendió el Programa las Víctimas contra las Violencias del Ministerio de Justicia y Derechos Humanos de la Nación, entre el 1 de octubre de 2019 y el 30 de septiembre de 2020, el 56,82% de los casos eran de NNyA1 (10.043 niñas, niños y adolescentes). Por otro lado, han ocurrido avances no sólo legislativos sino también institucionales y de gestión para mejorar el abordaje en estas situaciones, que incorporen de manera concreta procedimientos para proteger los derechos y la igualdad de género. Se cuenta, en este sentido, con protocolos de salud e intersectoriales, tanto a nivel nacional como provincial, que establecen estándares de atención para casos de abusos contra NNyA. Sin embargo, a partir de nuestra investigación2 constatamos que no existía un protocolo que permita estandarizar la articulación entre la actividad forense y clínico-asistencial, para la recolección, resguardo, preservación y cadena de custodia de evidencia biológica. El presente protocolo busca establecer criterios de trabajo y una metodología consensuada en materia probatoria respecto de los delitos sexuales contra NNyA. Fija estándares adecuados para la recolección, resguardo y preservación de la evidencia biológica, y enfatiza la importancia de que la toma de muestras se haga en forma oportuna en el marco de un abordaje integral de la situación, para así evitar la revictimización. Este protocolo modelo considera distintos escenarios según los recursos humanos y materiales disponibles en el lugar de la evaluación, y describe las condiciones mínimas para garantizar una evaluación adecuada que incluya el resguardo de la evidencia. En este sentido, este protocolo modelo pretende destacar la importancia de la participación del sector salud en articulación con el sector judicial, pues es usual que las víctimas llegan primero al ámbito asistencial sanitario y, por lo tanto, se requiere dar una respuesta estructurada en tres ejes esenciales: eficiencia, evitar la revictimización y el resguardo, cadena de custodia y documentacion de las muestras. De esta forma, se pretende dotar a todo el examen inicial de una visión asistencial que también pueda ser eficiente desde el punto de vista pericial.

Obesidade e sobrepeso em colaboradores de um Centro Universitário em Fortaleza ­ Ceará - Brasil: há diferença entre os sexos? / Obesity and overweight in collaborators of a University Center in Fortaleza ­ Ceará ­ Brazil: is there a difference between the sexes?

Objetivo: avaliar a prevalência de sobrepeso e obesidade de acordo com o sexo entre os colaboradores de um centro universitário. Métodos: trata-se de um estudo transversal realizado com funcionários de um centro universitário particular, localizado na cidade de Fortaleza ­ Ceará ­ Brasil. Foram coletados, em entrevista presencial, os seguintes dados: pessoais, socioeconômicos e demográficos, além de ter sido realizadas por equipe treinada, medidas antropométricas, tais como, peso, altura, circunferência do pescoço (CP) e circunferência da cintura (CC). Resultados: foram entrevistados 80 funcionários, a maioria do sexo feminino 65% e 40% na faixa etária entre 20 a 29 anos, 40,0% com ensino médio incompleto e 31,3% com renda de até um salário-mínimo mensal. De acordo com a classificação do estado nutricional segundo valores de Índice de Massa Corporal (IMC), 68,7% dos participantes apresentavam excesso de peso, considerando os colaboradores com sobrepeso e obesidade e 78,8% das mulheres apresentaram CC de risco moderado e alto para o desenvolvimento de doenças cardiovasculares (DCV). Os dados de CP mostraram que há uma prevalência elevada 77,5% de sobrepeso e obesidade em ambos os sexos. Do total, 75% das mulheres apresentaram risco nutricional antropométrico para desenvolver DCV, enquanto 60,7 % dos homens apresentaram parâmetros de risco, sem diferença estatística (p = 0,184). Conclusão: foi possível identificar que a maioria da população estudada apresenta excesso de peso segundo o IMC e CP, além de apresentar risco para o desenvolvimento de DCV analisados por meio da CC e RCE, sem diferença significativa entre os sexos. Ressalta, assim, a importância do atendimento nutricional para o diagnóstico precoce de sobrepeso/obesidade, com a finalidade de reduzir a prevalência de excesso de peso no ambiente de trabalho e no setor produtivo, com a realização de ações de conscientização da importância da alimentação e hábitos saudáveis na promoção da saúde e na prevenção de doenças crônicas não transmissíveis, como a obesidade

Objective: To assess the prevalence of overweight and obesity according to sex among employees of a university center. Methods: This is a cross-sectional study carried out with employees of a private university center located in the city of Fortaleza ­ Ceará ­ Brazil. Personal, socioeconomic, and demographic data were collected in a face-to-face interview, in addition to anthropometric measurements such as weight, height, neck circumference (NC), and waist circumference (WC) by a trained team. Results: 80 employees were interviewed, most of them 65% female and 40% aged between 20 and 29 years, 40.0% with incomplete high school education, and 31.3% with an income of up to one minimum monthly wage. According to the classification of nutritional status according to Body Mass Index (BMI) values, 68.7% of the participants were overweight, considering the overweight and obese employees, and 78.8% of the women had moderate-risk WC and high for the development of cardiovascular disease (CVD). The PC data showed that there is a high 77.5% prevalence of overweight and obesity in both sexes. Of the total, 75% of women had an anthropometric nutritional risk for developing CVD, while 60.7% of men had risk parameters, with no statistical difference (p = 0.184). Conclusion: It was possible to identify that the majority of the studied population is overweight according to BMI and LC, in addition to being at risk for the development of CVD analyzed through WC and WHtR, with no significant difference between genders. Thus, it emphasizes the importance of nutritional care for the early diagnosis of overweight/obesity to reduce the prevalence of excess weight in the work environment and the productive sector by carrying out actions to raise awareness of the importance of food and healthy habits in promoting health and preventing chronic non-communicable diseases such as obesity.

Prognostic Prediction of Cardiopulmonary Exercise Test Parameters in Heart Failure Patients with Atrial Fibrillation / Previsão Prognóstica dos Parâmetros do Teste de Esforço Cardiopulmonar em Pacientes com Insuficiência Cardíaca e Fibrilação Atrial

Abstract Background: Atrial fibrillation (AF) is associated with increased mortality in heart failure (HF) patients. Objective: To evaluate whether the risk of AF patients can be precisely stratified by relation with cardiopulmonary exercise test (CPET) cut-offs for heart transplantation (HT) selection. Methods: Prospective evaluation of 274 consecutive HF patients with left ventricular ejection fraction ≤ 40%. The primary endpoint was a composite of cardiac death or urgent HT in 1-year follow-up. The primary endpoint was analysed by several CPET parameters for the highest area under the curve and for positive (PPV) and negative predictive value (NPV) in AF and sinus rhythm (SR) patients to detect if the current cut-offs for HT selection can precisely stratify the AF group. Statistical differences with a p-value <0.05 were considered significant. Results: There were 51 patients in the AF group and 223 in the SR group. The primary outcome was higher in the AF group (17.6% vs 8.1%, p = 0.038). The cut-off value of pVO2 for HT selection showed a PPV of 100% and an NPV of 95.5% for the primary outcome in the AF group, with a PPV of 38.5% and an NPV of 94.3% in the SR group. The cut-off value of VE/VCO2 slope showed lower values of PPV (33.3%) and similar NPV (92.3%) to pVO2 results in the AF group. Conclusion: Despite the fact that AF carries a worse prognosis for HF patients, the current cut-off of pVO2 for HT selection can precisely stratify this high-risk group.

Resumo Fundamento: A fibrilação atrial (FA) está associada ao aumento da mortalidade em pacientes com insuficiência cardíaca (IC). Objetivo: Avaliar se o risco de pacientes com FA pode ser estratificado com precisão em relação aos pontos de corte do teste de esforço cardiopulmonar (TECP) para seleção do transplante cardíaco (TC). Métodos: Avaliação prospectiva de 274 pacientes consecutivos com IC com fração de ejeção do ventrículo esquerdo ≤ 40%. O endpoint primário foi um composto de morte cardíaca ou TC urgente no seguimento de 1 ano. O endpoint primário foi analisado através de vários parâmetros do TECP para a maior área sob a curva e para o valor preditivo positivo (VPP) e negativo (VPN) em pacientes com FA e ritmo sinusal (RS) para detectar se os atuais pontos de corte para a seleção de TC podem estratificar com precisão o grupo com FA. Diferenças estatísticas com valor de p < 0,05 foram consideradas significativas. Resultados: Havia 51 pacientes no grupo de FA e 223 no grupo RS. O endpoint primário foi maior no grupo FA (17,6% vs. 8,1%, p = 0,038). O valor de corte de pVO2 para a seleção do TC mostrou um VPP de 100% e um VPN de 95,5% para o endpoint primário no grupo FA, com um VPP de 38,5% e um VPN de 94,3% no grupo RS. O valor de corte da inclinação VE/VCO2 apresentou valores mais baixos de VPP (33,3%) e valor semelhante de VPN (92,3%) aos resultados de pVO2 no grupo FA. Conclusões: Apesar do fato de a FA apresentar um pior prognóstico para os pacientes com IC, o atual ponto de corte de pVO2 para a seleção de TC pode estratificar com precisão esse grupo de alto risco.

Reference values for the Unsupported Upper Limb Exercise test in healthy adults in Brazil / Valores normativos para o teste Unsupported Upper Limb Exercise para adultos saudáveis no Brasil

ABSTRACT Objective: To establish reference values for the Unsupported Upper Limb EXercise (UULEX) test, which measures peak arm exercise capacity, in healthy adults in Brazil. Methods: This was a cross-sectional study, involving presumably healthy individuals ≥ 30 years of age who completed questionnaires and underwent spirometry. All of the individuals underwent two UULEX tests 30-min apart. The outcome measure was the maximum time (in min) to completion of the test. Results: We included 100 individuals between 30 and 80 years of age. The mean test completion time was 11.99 ± 1.90 min among the women and 12.89 ± 2.15 min among the men (p = 0.03). The test completion time showed statistically significant correlations with age (r = −0.48; p < 0.001), gender (r = 0.28; p = 0.004), body mass index (BMI, r = −0.20; p = 0.05), and height (r = 0.28; p = 0.005). Linear regression analysis showed that the predictors of UULEX completion time were age (p = 0.000), BMI (p = 0.003), and gender (p = 0.019), which collectively explained 30% of the total variability. The mean UULEX completion time was 6% lower for the women than for the men. Conclusions: The present study was able to establish reference values for the UULEX test in healthy adults in Brazil. The values were influenced by age, gender, and BMI.

RESUMO Objetivo: Estabelecer valores normativos para o teste Unsupported Upper Limb EXercise (UULEX), que mede o pico de exercício de membros superiores, em adultos saudáveis no Brasil. Métodos: Estudo transversal envolvendo indivíduos com idade ≥ 30 anos considerados saudáveis após serem submetidos a questionários e espirometria. Os indivíduos realizaram dois testes UULEX com intervalo de 30 min entre eles. A variável de desfecho foi o tempo máximo de realização do teste em min. Resultados: Foram incluídos 100 indivíduos com idade entre 30 e 80 anos. As médias de tempo de realização do teste foram de 11,99 ± 1,90 min e 12,89 ± 2,15 min em homens e mulheres, respectivamente (p = 0,03). Houve uma correlação estatisticamente significante entre o tempo de execução do UULEX e idade (r = −0,48; p < 0,001), sexo (r = 0,28; p = 0,004), índice de massa corpórea (IMC; r = −0,20; p = 0,05) e altura (r = 0,28; p = 0,005). A análise de regressão linear mostrou que as variáveis idade (p < 0,001), IMC (p = 0,003) e sexo (p = 0,019) são preditoras do UULEX, explicando 30% da variabilidade total no tempo de realização do teste. A média do tempo de realização do UULEX foi 6% menor nas mulheres que nos homens. Conclusões: O presente estudo foi capaz de fornecer valores normativos para o teste UULEX em adultos saudáveis no Brasil. Esses valores foram influenciados pela idade, sexo e IMC.

Psychometric properties of Health Literacy in Dentistry scale in an elderly Brazilian population

Abstract This study aimed to assess the reliability and validity of Brazilian-Portuguese versions of the Health Literacy in Dentistry (HeLD) scale in a sample of elderly Brazilian participants. HeLD was initially translated into and cross-culturally adapted to the Brazilian Portuguese language. The reliability and validity of HeLD were then assessed in a sample of 535 non-institutionalized older persons who also completed a questionnaire containing sociodemographic and health information. Data were then randomly separated into two sub-datasets, and Confirmatory Factor Analysis was performed through structural equation modelling, with a maximum likelihood estimate to test the fit of the data to the factor structure of the long-and short-form HeLD (HeLD-29 and HeLD-14) versions of the instrument. The models were compared using the Akaike Information Criterion to assess goodness-of-fit and to determine which models were preferred. Internal consistency of HeLD was evaluated using Cronbach´s coefficient α. Both versions of HeLD were observed to demonstrate high internal reliability (Cronbach´s α ≥ 0.87 for all seven subscales), acceptable convergent (estimates of ≥ 0.50 for AVE and ≥ 0.70 for CR) and discriminant validity. However, the goodness-of-fit of the confirmatory factor analysis models demonstrated satisfactory results only for HeLD-14 subsamples (x2/df = 1.8-2.3; CFI = 0.97-0.98; GFI/NFI = 0.98-0.99; RMSEA = 0.05 and SRMR = 0.03). In conclusion, HeLD-14 was shown to be a reliable and valid instrument to measure oral health literacy in elderly Brazilian participants.

Linguistic and cultural adaptation to the Portuguese language of antimicrobial dose adjustment software / Adaptação linguística e cultural para a língua portuguesa de um software para ajuste de dose de antimicrobianos

ABSTRACT Objective To adapt an antibiotic dose adjustment software initially developed in English, to Portuguese and to the Brazilian context. Methods This was an observational, descriptive study in which the Delphi method was used to establish consensus among specialists from different health areas, with questions addressing the visual and operational aspects of the software. In a second stage, a pilot experimental study was performed with the random comparison of patients for evaluation and adaptation of the software in the real environment of an intensive care unit, where it was compared between patients who used the standardized dose of piperacillin/tazobactam, and those who used an individualized dose adjusted through the software Individually Designed and Optimized Dosing Strategies. Results Twelve professionals participated in the first round, whose suggestions were forwarded to the software developer for adjustments, and subsequently submitted to the second round. Eight specialists participated in the second round. Indexes of 80% and 90% of concordance were obtained between the judges, characterizing uniformity in the suggestions. Thus, there was modification in the layout of the software for linguistic and cultural adequacy, minimizing errors of understanding and contradictions. In the second stage, 21 patients were included, and there were no differences between doses of piperacillin in the standard dose and adjusted dose Groups. Conclusion The adapted version of the software is safe and reliable for its use in Brazil.

RESUMO Objetivo Adaptar um software de ajuste de dose de antibióticos inicialmente elaborado em língua inglesa para o português e a conjuntura brasileira. Métodos Trata-se de estudo observacional, descritivo, em que foi utilizado o método Delphi para estabelecer consenso entre especialistas de diferentes áreas da saúde, com perguntas que abordaram os aspectos visuais e operacionais do software. Em uma segunda etapa, foi realizado um estudo piloto, experimental, com alocação aleatória dos pacientes, para avaliação e adaptação do software em ambiente real de uma unidade de tratamento intensivo, onde foram comparadas diferenças entre pacientes que utilizaram dose padronizada usual de piperacilina/tazobactam, e os que utilizaram a dose individualizada ajustada por meio do software Individually Designed Optimum Dosing Strategies. Resultados Participaram da primeira rodada 12 profissionais cujas sugestões foram encaminhadas ao desenvolvedor do software para adequação e ajustes, e posteriormente submetidas à segunda rodada. Oito especialistas participaram da segunda rodada. Foram obtidos índices de 80% e 90% de concordância entre os juízes, caracterizando uniformidade nas sugestões. Dessa forma, houve modificação no layout do software para adequação linguística e cultural, minimizando erros de entendimento e contradições. Na segunda etapa, foram incluídos 21 pacientes, e não houve diferenças entre doses de piperacilina nos grupos dose padronizada e dose ajustada. Conclusão A versão adaptada do software é segura e confiável para seu uso no Brasil.

Description of a minimally invasive technique with a modified instrument for the osteosynthesis of proximal femoral fractures using the standard DHS and case series / Osteossíntese de fraturas do fêmur proximal minimamente invasiva com um instrumento modificado usando o DHS padrão: descrição de técnica e série de casos

ABSTRACT Introduction: the number of hip fractures is estimated to increase from 1.66 million in 1990 to 6.26 million by 2050. Internal fixation is the most common surgical treatment for intertrochanteric fractures. Objectives: the objective of the present research is to describe a minimally invasive technique with a modified instrument for the treatment of stable proximal femoral trochanteric fractures using the standard DHS, classified as Tronzo types 1 and 2 (AO 31A1.2), and presenting a case series. Methods: a case was selected to present the technique. Patients operated by this technique undergo a clinical evaluation and preoperative preparation as routine. The criteria for inclusion in the study were the presence of stable fracture of the proximal femur verified by two hip specialist orthopedists, and operated by the minimally invasive technique with a modified instrument using a standard DHS. Exclusion criteria were cases of patients operated for unstable fractures, and the use of other surgical techniques. A case series of 98 patients was performed and discussed. Results: minimally invasive technique with a modified instrument using the standard DHS device can reduce bleeding, it decreases soft tissue injuries, surgical time, and hospital stay, as any other MIPO procedures. Ninety-eight patients underwent the operation (Tronzo types I and II), 59 female and 39 male, ages from 50 to 85 years old. Immediate post-operative complications were shortening of the lower limb, loss of fracture reduction, and death by clinical complications. Conclusion: the present study describes a minimally invasive surgical technique using a modified instrument to perform proximal femoral osteosynthesis for stable trochanteric fractures, using the standard DHS.

RESUMO Introdução: estima-se que o número de fraturas de quadril aumente de 1,66 milhão em 1990 para 6,26 milhões em 2050. A fixação interna é o tratamento cirúrgico mais comumente utilizado para as fraturas intertrocantéricas. Objetivos: o objetivo da presente investigação é descrever uma técnica minimamente invasiva com um instrumento modificado para o tratamento de fraturas trocantéricas femorais proximais estáveis, classificadas como tipos I e II de Tronzo (AO 31A1.2), usando o DHS padrão, e apresentar uma série de casos. Métodos: foi selecionado um caso aleatório para apresentar a técnica. Os pacientes operados por essa técnica passam por avaliação clínica e preparo pré-operatório de rotina. Os critérios para inclusão no estudo foram a presença de fratura estável do fêmur proximal, verificada por dois ortopedistas especialistas em quadril, e operada pela técnica minimamente invasiva com um instrumento modificado usando um DHS padrão. Os critérios de exclusão foram os casos de pacientes operados por fraturas instáveis e o uso de outras técnicas cirúrgicas. Uma série de casos de 98 pacientes foi realizada e é discutida. Resultados: a técnica minimamente invasiva com o instrumento modificado usando o dispositivo DHS padrão pode reduzir a hemorragia, as lesões dos tecidos moles, o tempo cirúrgico e a estadia hospitalar, tal como quaisquer outros procedimentos de osteossíntese minimamente invasivos. Noventa e oito pacientes foram operados (tipos I e II de Tronzo), 59 do sexo feminino e 39 do masculino, com idades entre 50 e 85 anos. As complicações pós-operatórias imediatas foram encurtamento do membro inferior, perda da redução da fratura e morte por complicações clínicas. Conclusão: o presente estudo descreve uma técnica cirúrgica minimamente invasiva, utilizando um instrumento modificado para realizar osteossíntese femoral proximal para fraturas trocantéricas estáveis, utilizando o DHS padrão.

Estandarización de una técnica en el tiempo y su impacto en los resultados para hiperhidrosis palmar primaria / Our technique standardization on time and how impact over outcomes for primary palmar hiperhidrosis

Resumen Introducción: La hiperhidrosis palmar primaria es un problema médico frecuente. Minimizar la invasión, simplificar y estandarizar la técnica supone mejores resultados. Objetivo: Evaluar eficacia y seguridad con la aplicación de nuestra técnica simplificada y estandarizada, a través de su impacto en los resultados trans y postoperatorio para la hiperhidrosis palmar primaria (HPP). Materiales y Método: Se realiza estudio observacional que evalúa los resultados obtenidos con la aplicación de nuestra técnica estandarizada para el tratamiento de HPP. El universo está constituido por 359 pacientes intervenidos entre 2007 y 2011. El control hasta los 5 años fue posible en 298, los que constituyeron la muestra definitiva. Resultados: Se analizaron 298 pacientes (596 procedimientos). En el transoperatorio solo 3 pacientes (1%) presentaron alguna complicación. El manejo del dolor torácico fue la mayor dificultad inmediata a la cirugía, con 61,7% de dolor moderado y 15,2% severo. Último control a 5 años con curación en el 99,7% y una recidiva. Los índices de satisfacción se muestran en rango excelente según encuestas validadas. Manejo ambulatorio en 99%. Discusión: Aplicar intubación endotraqueal simple permite extrapolar ventajas ya conocidas de esta técnica y menos complicaciones respiratorias, suspensiones, uso de recursos costosos o personal muy calificado. La combinación de simplificar aspectos quirúrgicos y anestésicos permitieron estandarizar y simplificar nuestra técnica y con ello: no necesitar drenajes pleurales, menos dolor, recuperación casi inmediata de la fisiología respiratoria y alta precoz. Conclusión: Combinar el empleo de tubo endotraqueal simple y oxigenación apneíca con minimizar la invasión quirúrgica: puerto único, sin drenaje pleural y manejo ambulatorio constituyen una práctica segura para la simpatectomía torácica endoscópica, con mejores resultados postoperatorios, una vez logrado en entrenamiento necesario.

Introduction: Primary palmar hyperhidrosis is a frequent medical problem. Minimizing invasion, simplifying and standardizing technique means better results. Aim: To evaluate efficacy and safety with the application of our simplified and standardized technique, through its impact on trans and post-operative outcomes for primary palmar hyperhidrosis (PPH). Minimizing approach, simplifying and standardizing the technique should lead to better outcomes. Materials and Method: An observational study is carried out to evaluate the outcomes obtained with the application of our standardized technique for the treatment of PPH. The universe constituted by 359 patients treated between 2007 and 2011. Control up to 5 years was possible in 298, which constituted the definitive sample. Results: 298 patients (596 procedures) were analyzed. In the transoperative only 3 patients (1%) report minor complication. Thoracic pain management was the greatest difficulty immediate to surgery, with 61.7% moderate pain and 15.2% severe. Satisfaction indexes in excellent range according to validated surveys. Outpatient management in 99%. Discussion: Simple intubation avoids respiratory complications, suspensions, use of expensive resources or highly qualified personnel. Early pain relief, non-uses of pleural tubes or antibiotics allows rapid recovery and early discharge due to simplification and standardization of the technique. Conclusion: The use of simple endotraqueal tube and oxygenation in apnea, single port, without pleural drainage or antibiotics and ambulatory is a safe practice for endoscopic thoracic sympathectomy, once achieved in necessary training.

Propiedades psicométricas de la escala APGAR-familiar en personas mayores residentes en zonas rurales multiétnicas chilenas / Psychometric properties of APGAR-family scale in a multiethnic sample of Chilean older people

Background: The APGAR-family scale is used for the assessment of family functioning in primary health care. Aim: To examine the psychometric properties of the family functioning scale APGAR-family, in a multi-ethnic sample of older Chilean adults. Material and Methods: The scale was applied to 800 participants aged more than 60 years, residing in rural areas of the regions of Arica and Parinacota and La Araucanía. Results: The Cronbach's alpha obtained was 0,992 for the scale composed of five items. The confirmatory factor analysis determined a unifactorial model, whose goodness of fit indices were satisfactory. Namely, weighted least square mean and variance adjusted-χ2 was 20.097 (p < 0.01), comparative fit index was 0.997, Tucker-Lewis index was 0.995 and Root Mean Square Error of Approximation was 0.079 (90% confidence intervals 0.049-0.091). Conclusions: The APGAR-family is a reliable and appropriate instrument to be applied in older people in Chile, specifically in elderly people residing in rural areas who belong to the Aymara and Mapuche indigenous communities.

Análisis de las cesáreas en Uruguay por tipo de centro hospitalario / An analysis of caesarean sections in Uruguay by type of hospital

Objetivo: Analizar comparativamente la incidencia de las cesáreas en los subsistemas de salud de Uruguay y en relación con los estándares de la Organización Mundial de la Salud (OMS) considerando las características médico-obstétricas de los partos, en especial la clasificación de Robson. Método: Se emplean 190.847 nacimientos registrados en el Sistema Informático Perinatal de Uruguay entre 2009 y 2014 por tipo de subsector sanitario. Mediante modelos logit se analiza la probabilidad de cesárea considerando la clasificación de Robson, otros factores de riesgo y las características de las madres. Se comparan las tasas de cesárea predichas por los distintos subsectores sanitarios para una población común. Asimismo, se contraponen las tasas de cesáreas observadas en cada subsistema con las que, hipotéticamente, se encontrarían si los hospitales siguiesen las pautas de la muestra de hospitales de referencia de la OMS. Resultados: El subsector privado, en términos generales, presenta una incidencia de cesáreas mucho más elevada que el público, incluso después de considerar las características médico-obstétricas de los nacimientos. Las tasas de cesáreas en Uruguay están más de un 75% por encima del valor que cabría esperar de acuerdo con el modelo de la OMS. Conclusiones: La incidencia de cesáreas en Uruguay es muy alta respecto a los estándares definidos por la OMS, en especial en el subsector privado. Este hecho no se explica por las características clínicas de los nacimientos.

Objective: To analyse on a comparative basis the incidence of caesarean sections among the different health care systems in Uruguay and with respect to the World Health Organization's (WHO) standards, taking into account the medical-obstetric characteristics of the births, particularly, the Robson classification. Methods: We examine 190,847 births registered by the Perinatal Information System in Uruguay between 2009 and 2014 by type of health care system. Using logit models, we analyse the probability of caesarean section taking into account the Robson classification, other risk factors and the mothers' characteristics. We compared the caesarean rates predicted by the different subsystems for a common population. Furthermore, we contrast the caesarean rates observed in each subsystem with the rates that resulted if the Uruguayan hospitals followed the guidelines of the sample of WHO reference hospitals. Results: Private health systems in Uruguay exhibit a much higher incidence of caesarean sections than public ones, even after considering the medical-obstetric characteristics of the births. Caesarean rates are more than 75% higher than those observed if the WHO standards are applied. Conclusions: Uruguay has a very high incidence of caesarean sections with respect to WHO standards, particularly, in the private sector. This fact is unrelated to the clinical characteristics of the births.

Correlation of tools for objective evaluation of infravesical obstruction of men with lower urinary tract symptoms

ABSTRACT Purpose To identify how the most frequently used parameters in daily clinical practice diagnosing bladder outlet obstruction (BOO) due to benign prostate hyperplasia (BPH) correlate to each other. Materials and methods The study included 452 patients with lower urinary tract symptoms (LUTS) of the UNICAMP urology outpatient clinic of LUTS. Inclusion criteria: patients with BOO due to BPH who agreed to participate in the study. Exclusion criteria: patients with urinary tract infection, neurological diseases that compromised the lower urinary tract, prior prostatic surgery, radiotherapy or urethral stenosis. Patient assessment: history, international prostate symptoms score (IPSS), nocturnal quality of life score (NQoL) questionnaires, physical and digital rectal examination (DRE), PSA, transabdominal ultrasound with intravesical prostate protrusion (IPP), post-mictional residue and free uroflowmetry. Results There was no strong Spearman correlation among the studied variables. The only moderate correlations occurred between IPSS and NQoL (p <0001; c=0.56) and between IPP and prostate volume (p <0001; c=0.57). Weak correlations between IPP and post-mictional residue (p <0001; c=0.31) and free uroflowmetry (p <0001; c=-0.26); and between IPSS and free uroflowmetry (p <0001, c=-0.21) were observed. Conclusion In this study, we found moderate, weak, very weak and absent correlation among the various parameters used in the diagnosis and management of BOO due to BPH. As the value of these tools is variable, the creation of a logical and objective algorithm was not possible and the treatment is based on the interpretation of clinical symptoms.

El médico humanista, cumple su solidaria labor buscando tanto el bienestar de sus pacientes, así como su dedicación a la investigación innovadora y la transmisión de sus conocimientos a quienes lo requieren. [Editorial] / The humanist doctor, fulfills his solidarity work seeking both the well-being of his patients, as well as his dedication to innovative research and the transmission of his knowledge to who require it. [Editorial]

El médico humanista, cumple su solidaria labor buscando tanto el bienestar de sus pacientes, así como su dedicación a la investigación innovadora y la transmisión de sus conocimientos a quienes lo requieren. Se convierte entonces en un verdadero creador, enseñando honestidad científica y estándares altos de conducta hacia sus colegas y estudiantes. La atención médica dentro de la Seguridad Social se presenta como una política de promoción y desarrollo de programas médicos sociales, que basados en el criterio de la solidaridad, protección del capital humano y fuerza de trabajo, tratan de dar atención en salud a una población cada vez más amplia, la que junto con la cobertura de otras contingencias vitales busca cumplir con los objetivos de bienestar de la población en general.

Cross-cultural adaptation and validation of the neurogenic bladder symptom score questionnaire for brazilian portuguese

ABSTRACT Objective: To cross-culturally adapt and check for the reliability and validity of the neurogenic bladder symptom score questionnaire to Brazilian Portuguese, in patients with spinal cord injury and multiple sclerosis. Materials and Methods: The questionnaire was culturally adapted according to international guidelines. The Brazilian version was applied in patients diagnosed with neurogenic bladder due to spinal cord injury or multiple sclerosis, twice in a range of 7 to 14 days. Psychometric properties were tested such as content validity, construct validity, internal consistency, and test-retest reliability. Results: Sixty-eight patients participated in the study. Good internal consistency of the Portuguese version was observed, with Cronbach α of 0.81. The test-retest reliability was also high, with an Intraclass Correlation Coefficient of 0.86 [0.76 - 0.92] (p<0.0001). In the construct validity, the Pearson Correlation revealed a moderate correlation between the Portuguese version of the NBSS and the Qualiveen-SF questionnaire (r = 0.66 [0.40-0.82]; p <0.0001). Conclusions: The process of cross-cultural adaptation and validation of the NBSS questionnaire for the Brazilian Portuguese in patients with neurogenic lower urinary tract dysfunction was concluded.

Impact of PI-RADS v2 on indication of prostate biopsy

ABSTRACT Objectives: To identify the group of patients who could safely avoid prostate biopsy based on the findings of multiparametric prostate resonance imaging (MRmp), parameterized with PI-RADS v2, using prostate biopsy as reference test and to assess the sensitivity and specificity of mpMR in identifying clinically significant prostate cancer using prostate biopsy as a reference test. Patients and Methods: Three hundred and forty two patients with suspected prostate cancer were evaluated with mpMR and prostate biopsy. Agreement between imaging findings and histopathological findings was assessed using the Kappa index. The accuracy of mpMR in relation to biopsy was assessed by calculations of sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV). Results: A total of 342 biopsies were performed. In 201 (61.4%), mpMR had a negative result for cancer, which was confirmed on biopsy in 182 (53%) of the cases, 17 (4.9%) presented non-clinically significant cancer and only 2 (0.5%) clinically significant cancer. 131 (38.3%) patients had a positive biopsy. Clinically significant cancer corresponded to 83 (34.2%), of which 81 (97.5%) had a positive result in mpMR. Considering only the clinically significant cancers the mpMR had a sensitivity of 97.6%, specificity of 76.8%, PPV 57.4% and VPN of 99%. Conclusions: mpMR is a useful tool to safely identify which patients at risk for prostate cancer need to undergo biopsy and has high sensitivity and specificity in identifying clinically significant prostate cancer.

¿Qué representa cambiar el umbral diagnóstico de la hipertensión arterial? Guías ACC/AHA 2017 y su aplicación en Perú / Changes in the prevalence of hypertension in Peru using the new guideline of the American College of Cardiology

Introduction and Objective: There is little evidence in Latin America about the impact of the ACC/AHA 2017 guideline. Taking as reference the JNC 7 guideline, the objective of our study is to estimate changes in the prevalence of arterial hypertension (HBP) according to socio-demographic characteristics and geographic regions, applying the criteria of the new ACC / AHA guide 2017. Methods: Cross-sectional study of the Demographic and Family Health Survey conducted in Peru in 2017. Standardized weighted hypertension prevalence's were estimated for the WHO population according to both guidelines, and absolute differences with 95% CI. Results: We included 30,682 people aged 18 years and over, with an average age of 42.3 years, 51.1% women. The standardized prevalence of HBP for 2017 according to JNC 7 was 14.4% (95% CI: 13.8-15.1) and according to ACC / AHA 2017 it was 32.9% (95% CI: 32.0-33.7), so the prevalence increase is 18.5 percentage points, being higher in males than females (24.2 vs 12.9 respectively). In people with obesity and / or who consume tobacco, the increases were higher (24.3 and 24.1 percentage points respectively). In the regions of Tacna, Ica and Metropolitan Lima, the increase, in comparison with the JNC 7 guidelines, overcome the national average (22.4, 20.7 and 20.4, percentage points, respectively). Conclusions: Considering the context of a Latin American country and knowing the epidemiology of hypertension in Peru, the potential adoption of the ACC/AHA 2017 guidelines for the prevention, detection, evaluation, and management of hypertension should be accompanied by an evaluation of the impact at the individual, system and social level.

A Proposed Inflammatory Score of Circulating Cytokines/Adipokines Associated with Resistant Hypertension, but Dependent on Obesity Parameters / Proposta de um Escore Inflamatório de Citocinas e Adipocinas Plasmáticas Associado à Hipertensão Resistente, mas Dependente dos Parâmetros de Obesidade

Abstract Background: There is evidence that subclinical systemic inflammation is present in resistant hypertension (RHTN). Objective: The aim of the study was to develop an integrated measure of circulating cytokines/adipokines involved in the pathophysiology of RHTN. Methods: RHTN (n = 112) and mild to moderate hypertensive (HTN) subjects (n=112) were studied in a cross-sectional design. Plasma cytokines/adipokines (TNF-alpha, interleukins [IL]-6, -8, -10, leptin and adiponectin) values were divided into tertiles, to which a score ranging from 1 (lowest tertile) to 3 (highest tertile) was assigned. The inflammatory score (IS) of each subject was the sum of each pro-inflammatory cytokine scores from which anti-inflammatory cytokines (adiponectin and IL-10) scores were subtracted. The level of significance accepted was alpha = 0.05. Results: IS was higher in RHTN subjects compared with HTN subjects [4 (2-6) vs. 3 (2-5); p = 0.02, respectively]. IS positively correlated with body fat parameters, such as body mass index (r = 0.40; p < 0.001), waist circumference (r = 0.30; p < 0.001) and fat mass assessed by bioelectrical impedance analysis (r = 0.31; p < 0.001) in all hypertensive subjects. Logistic regression analyses revealed that IS was an independent predictor of RHTN (OR = 1.20; p = 0.02), independent of age, gender and race, although it did not remain significant after adjustment for body fat parameters. Conclusion: A state of subclinical inflammation defined by an IS including TNF-alpha, IL-6, IL-8, IL-10, leptin and adiponectin is associated with obese RHTN. In addition, this score correlates with obesity parameters, independently of hypertensive status. The IS may be used for the evaluation of conditions involving low-grade inflammation, such as obesity-related RHTN. Indeed, it also highlights the strong relationship between obesity and inflammatory process.

Resumo Fundamento: Evidências indicam que a inflamação sistêmica subclínica está presente na hipertensão arterial resistente (HAR). Objetivo: Desenvolver uma medida que integra citocinas envolvidas na fisiopatologia da HAR. Métodos: Indivíduos com HAR (n = 112) e indivíduos com hipertensão leve a moderada (HT) (n = 112) foram estudados em delineamento transversal. Valores de citocinas/adipocinas plasmáticas [TNF-alfa, interleucinas (IL)-6, -8, -10, leptina e adiponectina] foram divididos em tercis, e lhes atribuído um escore variando de 1 (tercil mais baixo) a 3 (tercil mais alto). O escore inflamatório (EI) de cada participante foi calculado como a soma do escore de cada citocina pró-inflamatória da qual subtraiu-se o escore de cada citocina anti-inflamatória (adiponectina e IL-10). O nível de significância aceito foi alfa = 0,05. Resultados: O EI foi mais alto nos indivíduos com HAR em comparação a indivíduos com HT [4 (2-6) vs. 3 (2-5); p = 0,02, respectivamente]. O EI correlacionou-se positivamente com parâmetros de gordura corporal, tais como índice de massa corporal (r = 0,40; p < 0,001), circunferência da cintura (r = 0,30; p < 0,001) e massa gorda avaliada por bioimpedância (r = 0,31; p < 0,001) em todos os indivíduos hipertensos. Análises de regressão logística mostraram que o EI foi um preditor independente de HAR (OR = 1,20; p = 0,02), independentemente de idade, sexo e raça; porém, o modelo perdeu significância estatística após ajuste para os parâmetros de gordura corporal. Conclusão: Um estado de inflamação subclínica definida pelo EI incluindo TNF-alfa, IL-6, IL-8, IL-10, leptina e adiponectina está associado com indivíduos obesos com HAR. Além disso, o escore correlaciona-se com parâmetros de obesidade, independentemente do grau de hipertensão. O EI pode ser usado na avaliação de condições que envolvem inflamação subclínica, tal como HAR relacionada à obesidade. O estudo também destaca a forte relação entre obesidade e inflamação.